Cystic+Fibrosis

=**Everett Green and Jack Barry Date: 3/7/11 Score:**= =** Genetic Disorder Assignment--Cystic Fibrosis **=
 * ====**1. Causes:**==== || ====Cystic Fibrosis is caused by a defective autosomal gene which causes the body to produce abnormally thick and sticky fluids. ==== ||
 * ==== **2. What is the Pattern of Inheritance:** ==== || ====Millions of Americans have the CF gene but for someone to have any symptoms, the gene must be inherited by both parents. (Multiple allele recessive) ==== ||
 * ====**3. Characteristics of the Disorder:**==== || ==== 1 in every 29 Caucasian americans are born with the disease. Most commonly affecting Caucasian Americans. It's more common among those of Northern or Central European descent. ==== ||
 * ====**Cont. of Characteristics:**==== || ==== Cystic fibrosis (CF) is caused by a defective gene which causes the body to produce abnormally thick and sticky fluid, called mucus. This mucus builds up in the breathing passages of the lungs and in the pancreas, the organ that helps to break down and absorb food. ====

[[image:mcdc7_cystic_fibrosis.jpg]]
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 * ====**Treatments:**==== || * ==== Antibiotics to prevent and treat lung and sinus infection s. They may be taken by mouth, or given in the veins or by breathing treatments. People with cystic fi brosis may take antibiotics only when needed, or all the time. Doses are usually higher than normal.====
 * ====Inhaled medicines to help open the airways====
 * ====DNAse enzyme replacement therapy to thin mucus and make it easier to cough up====
 * ====Flu vaccine and [|pneumococcal polysaccharide vaccine] ([|PPV]) yearly (ask your health care provider)====
 * ====[|Lung transplant] is an option in some cases====
 * ==== Oxygen therapy may be needed as lung disease gets worse ==== ||
 * ====**5. Prevention:**==== || ====**No**====

It cannot be prevented because it is a genetic disease.
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 * ====**6. Testing:**==== || ====**Yes**====

A blood test is available to help detect CF. The test looks for variations in a gene known to cause the disease. Other tests use to diagnose CF include:

 * ==== Immunoreactive trypsinogen test(IRT), which is a standard newborn screening test for CF. A high level of IRT suggests possible CF and requires further testing. ====
 * ==== [|Sweat chloride test] i s the standard diagnostic test for CF. A high salt level in the patient's sweat is a sign of the disease. ==== ||

Interesting facts about Cystic Fibrosis:
-More than 1,000 different mutations in the CFTR gene have been identified in cystic fibrosis patients. The most common mutation (observed in 70% of cystic fibrosis patients) is a three-base deletion in the DNA sequence, causing an absence of a single amino acid in the protein product. -About 2,500 babies are born with cystic fibrosis in the U.S. each year. -More than 10 million Americans carry the cystic fibrosis gene but don't know it.